LUDWIGSHAFEN, Germany - At least one person has died and six people injured in an explosion and fire at chemical company BASF’s site in Ludwigshafen, Germany. The company reports that another six people are not yet accounted for.

According to the Associated Press, Plant Manager Uwe Liebert reported the explosion happened after a fire broke out in a pipeline where liquids are loaded and unloaded.

In a press conference held this morning, the company said that it does not yet know the cause of the explosion, and that the substances involved were not currently identified.

Various news organizations are reporting that residents in parts of Ludwigshafen and Mannheim, on the other side of the Rhine, have been advised to stay indoors.  

The Ludwigshafen research and production site employs over 39,000 individuals and is the location of the company’s headquarters. The plant is BASF’s largest production site worldwide.